Solubility and permeability are most prerequisite for oral absorption of drugs to achieve maximum bioavailability from a dose of drug. Telmisartan is an angiotensin receptor blocker with poor aqueous solubility due to which its bioavailability is very less. For enhancing solubility & dissolution rate of Telmisartan a novel porous drug matrices are formulated by emulsification followed by spray drying. The porous drug matrices of Telmisartan is prepared by using hydrophilic non-ionic surfactant of general class copolymers such as Polaxomer 407(PXM 407), Poly vinyl Pyrrolidone (PVP K30) as a hydrophilic carriers and Hexane as a liquid pore forming agent. Various Drug: Polymers ratios are used to know the effect of polymer concentration on solubility and dissolution rate. Physical mixtures are formulated with drug and polymer. All the formulations (Physical mixtures and porous drug matrices) were subjected to IR spectral analysis & Dissolution studies to investigate compatibility as well as effect of method on dissolution rate. The dissolution rate is aimed to enhance by enhancing surface area by increasing porosity. The dissolution studies are characterized using USP dissolution apparatus II at 50 rpm. From the dissolution data porous drug matrices with PVP K30 having drug: polymer ratio of 1:4 showed more dissolution rate. The Q value was achieved within 20 minutes and 100% drug release was achieved within 60 minutes. The application of Hixson and crowells model has regression values of 0.999 conforming the influence of porous drug matrices on surface area. The kinetic analysis of dissolution data showed that Telmisartan followed first order release from porous drug matrices.
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